Flexible Options Research Articles

Nagynyomású hidrogénatmoszférás kemence gyártása szénacélok elridegedésének vizsgálatához

Összefoglalás. A hidrogén tárolása iránti igény egyre növekszik, melynek oka az, hogy a hidrogén mint alternatív energiahordozó jelentős szerepet játszik a szén-dioxidkibocsátás-csökkentési törekvésekben. Azonban, az elridegedési folyamatok körében a hidrogén által előidézett károsodások jelentik a legkomolyabb problémát az acélokra nézve. Kutatómunkánk során egy nagynyomású hidrogénatmoszférás hőkezelésre alkalmas autoklávot terveztünk, majd gyártottunk. Az autoklávban P355 NH minőségű alapanyagból kimunkált szabványos Charpy-féle ütőpróbatesteket hőkezeltünk 150 °C-on, 40 bar túlnyomáson, 200 órán keresztül, tiszta hidrogén atmoszférában. A vizsgálatok eredményei alapján megállapítottuk, hogy a jelentős mértékű elridegedés a hidrogénezési folyamat után sem történt. Summary. The demand for hydrogen storage is growing. The primary reason for this is that hydrogen as an alternative energy carrier is playing a significant role in carbon reduction efforts as a fuel for road and maritime transport. In addition, hydrogen can be seen as a long-term flexible energy storage option. Hydrogen as an energy carrier is expected to play a significant role in residential and industrial use in the future. A first step in this development is the mixing of hydrogen with natural gas in small quantities. Increasing the share of hydrogen would not only reduce CO2 emissions, but would also facilitate the development of different hydrogen production methods and thus reduce production costs. The upper safety limit for hydrogen blending with natural gas is set by the national specification of the natural gas supply, possible material quality restrictions and the tolerance of the most sensitive equipment in the network. For this reason, the maximum allowable hydrogen content in natural gas is generally limited to 2,5%. However, among the embrittlement processes, hydrogen-induced damage is the most serious problem for both non-alloy and low-alloy steels. Atomic hydrogen diffuses in steel at high rates. The diffusion rate is orders of magnitude higher than that of other elements; this is due to the small atomic diameter of hydrogen. To investigate the degradation of different carbon steels in a high-pressure hydrogen atmosphere, a hydrogenation furnace was designed and fabricated at the Department of Materials Science and Engineering at BME. The hydrogenation furnace is the main part of a complex mechanical engineering system, for the operation of which the mechanical, heating, electrical supply, control and gas handling components are indispensable. The entire design process of the furnace was led by József Blücher, Professor Emeritus at BME, with the help of the engineers and technicians working on the project. Standard Charpy impact test specimens were machined from P355 NH grade material to test the embrittlement of carbon steels. The hydrogenation temperature was 150 °C, the internal overpressure in the chamber was 40 bar, the hydrogenation time was 200 hours and the atmosphere was hydrogen gas of purity 5.0. The impact test was carried out at -20, 0 and +20 °C. Based on the results of the tests, it can be concluded that there was no significant degree of degradation both before hydrogenation and after prolonged exposure to hydrogen. It can be concluded that the tube material used as a sample is suitable for operation in a hydrogen medium. Based on the analysis of the burst areas and impact values of the impact test specimens, it was concluded that hydrogen did not cause any observable damage to the test material.

Curriculum leadership in a rural indigenous high school in Taiwan implementing the 108 Curriculum Guidelines

Curriculum leadership in a rural indigenous high school in Taiwan implementing the 108 Curriculum Guidelines

Skilling in the Informal Economy in India: Identifying and Addressing Inequities in Designing and Delivering Lifelong Learning Opportunities

Lifelong learning opportunities (LLOs) for adults enhance their capabilities and resilience in adapting to changing circumstances, especially in the context of livelihoods. However, informal economy workers face barriers to accessing LLOs, including the digital divide among other challenges. An action research case study of an Indian LLO provider shifting to hybrid vocational education reveals the potential of digital LLOs, where low mobile data costs, high phone penetration, and flexible options mitigate learning expenses. The study details the constraints that the informal economy learners and the LLO providers face and thus contributes to the literature analyzing the broader implications of market changes and skill development for sustainable development.

Abstract PO1-26-04: Patient-derived organotypic tissue cultures for organoid isolation and probing unique metabolic features of individual breast cancer patients

Abstract Patient-derived organotypic tissue cultures (PD-OTC) are unique models for probing how individual patient’s tumor microenvironment (TME) influences cancer development and treatment responses. They retain the patient tumor architecture and TME, that are difficult to recapitulate in other models, while affording flexible treatment options and comparison of cancer (CA) versus matched non-cancer (NC) tissue responses to treatments. We have developed a culturing method for establishing PD-OTC of breast cancer patients that exhibit CA tissue growth and extensive metabolic reprogramming between CA versus matched NC tissues while enabling patient-derived organoids (PDO) and fibroblasts to be isolated. Pairs of CA and NC tissues freshly resected from six patients bearing early-stage estrogen receptor/progesterone receptor positive ductal carcinoma were sliced at 750 µm, embedded in Matrigel, and cultured in a 6-well plate with a Biopore membrane insert and custom medium at 37°C/5% CO2 with gentle rocking (16-40 mg wet weight; n=3). Excess tissue slices were cryopreserved and kept at -196 °C. Culture media were sampled periodically for metabolite analysis by NMR. Microscopic examination revealed significant tissue, organoid-like, and fibroblast outgrowth after 1-1.5 month of culturing. Two to three days prior to the harvest of two patients’ (CZ16 and 17) OTC, the culture medium was replaced with [U-2H]-glucose + [U-13C,15N]-glutamine-containing medium to allow the two stable isotope tracers to be metabolized, followed by Stable Isotope-Resolved Metabolomic (SIRM) analysis by NMR and ion chromatography coupled with ultra high-resolution Fourier transform mass spectrometry (IC-UHRFTMS). Two separate pieces of the OTC were cut and each was assayed for glucose uptake and mitochondrial membrane potential by live fluorescence spectroscopy via a portable custom-built fluorescence microscope, and by histochemical analysis. Histological analysis showed that both CA and NC OTC of all patients maintained their structural integrity. SIRM analysis of two patients’ OTC revealed active catabolic and anabolic metabolism including glucose uptake/glycolysis, the Krebs cycle/mitochondrial membrane potential, the pentose phosphate pathway (PPP), gluconeogenesis, glycogen synthesis, and purine/pyrimidine/sugar nucleotides synthesis. The CA OTC of both patients showed enhanced glucose uptake, glycolysis, mitochondrial membrane potential/Krebs cycle, PPP, glycogen synthesis, and purine nucleotide synthesis, when compared with the matched NC OTC. Treatment-naïve CA OTC of CZ16 showed much more significant metabolic reprogramming (NAD+ metabolism, in particular) than CA OTC of CZ17 who has undergone neoadjuvant treatment, chemotherapy, and hormone therapy prior to surgery. Distinct metabolic features of breast CA tissues can be exploited as therapeutic targets. Organoids and fibroblasts were isolated from CA and/or NC OTC cultures and their characterization is in progress. When revived, cryopreserved OTC exhibited active metabolism and tissue/organoid/fibroblast outgrowth similarly to fresh OTC. In conclusion, our culturing method enables PD-OTC models to be established efficiently for early-stage breast cancer patients for downstream functional studies including live cell imaging and SIRM analysis. Organoids and fibroblasts can also be derived from < 20 mg of tissues for further studies. Future direction includes therapeutic studies on these patient-derived models to better understand and predict individual patient’s responses to therapy. Citation Format: Teresa Fan, Carlos Goncalves, Jing Yan, Jahid Islam, Penghui Lin, Mohamed Kaddah, Richard Higashi, Andrew Lane, Caigang Zhu. Patient-derived organotypic tissue cultures for organoid isolation and probing unique metabolic features of individual breast cancer patients [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO1-26-04.

GORE-TEX SUTURE-ASSOCIATED ENDOPHTHALMITIS IN A SCLERAL-SUTURED INTRAOCULAR LENS.

To describe a unique case of Gore-Tex (Gore Medical, AZ) suture-associated delayed-onset endophthalmitis in a patient with a history of scleromalacia, pathologic myopia, multiple prior vitrectomies in the setting of a scleral-sutured intraocular lens (IOL). A 69-year-old man complained of blurry vision and eye pain 21 months after implantation of a scleral-sutured IOL and was found to have an exposed Gore-Tex suture with scleromalacia, vision loss to hand motion, a hypopyon, and vitritis. He was diagnosed with culture-positive endophthalmitis. He had a previous history of a rhegmatogenous retinal detachment repair and subsequent dislocated IOL in this eye treated with a scleral-sutured IOL. A vitreous tap and injection of broad-spectrum antibiotics and suture removal at the slit lamp were performed at the time of presentation. One week later, he underwent pars plana vitrectomy and removal of the IOL. After the tap and inject and subsequent lens removal, his vision has returned to his preoperative vision of 20/100 with refraction. Gore-Tex suture is a nonabsorbable and flexible option with great tensile strength that has emerged as a favored alternative to polypropylene for the use in transscleral fixated IOLs. Although endophthalmitis and suture erosion are known complications of this procedure, this report describes one of the first cases of Gore-Tex suture-associated endophthalmitis.

Redefining the relationship in digital care: A qualitative study of the Digital Therapeutic Alliance

Digital therapeutic programs are emerging almost daily, offering the potential to reduce healthcare access inequalities by providing more flexible and accessible care options. However, as with traditional healthcare, the issue of patient engagement is fundamental, and the latest research have reported that fewer than 30% of users complete these programs in their entirety. Hence, many authors emphasize the importance of studying the role of therapeutic alliances specifically adapted to digital care. The therapeutic alliance encompasses the collaborative aspects of the relationship between the therapist and the patient. In this context there is a need to reconceptualize the alliance within the context of digital healthcare as it can enhance engagement, adherence, and the effectiveness of such treatments. The objective of this qualitative study was to identify the components of the digital therapeutic alliance. A thematic analysis has identified three major themes that appear to constitute the digital therapeutic alliance among 44 users of an online program: trust in the program, perception of interactions, and feeling of consideration. These results prompted a discussion of the challenges of digital healthcare, including the terminology to use. The term “digital therapeutic adherence” is proposed, thereby opening up a field for research and clarification of this important concept distinct from traditional alliance.

Cereal rye cover crop termination at or before soybean planting has minimal effect on soybean yield across the midwestern US

ContextInterest is growing among farmers in the Midwestern US region in the potential benefits of establishing cereal rye (Secale cereale L.) as a cover crop. However, they are concerned about the implications and potential trade-offs due to this practice. ObjectiveWe aimed to evaluate the effects of cereal rye cover crop termination at or before soybean planting on soybean (Glycine max [L.] Merr.) seed yield. MethodsField experiments were conducted from 2019 to 2021 across 28 location-years in the Midwestern US. Treatments consisted of no cereal rye, cereal rye termination before soybean planting, and termination at planting. Cereal rye was chemically terminated at each termination timing. Cereal rye biomass and soybean yield were assessed. ResultsDelaying cereal rye termination in soybean systems increased rye biomass, but its impact on soybean yield was inconsistent. Results showed that delayed termination did not reduce soybean seed yield in 25 of 28 location-years compared to a no cover crop treatment. There was no clear evidence indicating that a threshold level of cereal rye biomass accumulation reduced soybean seed yield. ConclusionsOur results suggest that farmers who adopt cereal rye as a winter cover crop in the examined region have a flexible management window for terminating cereal rye, as the timing of termination had minimal effect on soybean seed yield. However, there were no significant soybean seed yield benefits that would justify the associated cost with the use of cover crops. Therefore, conducting long-term studies in the future is highly recommended to better understand how cereal rye cover crops can influence soybean seed yield and soil quality properties over time. Further studies should also investigate the aspect of non-chemical rye management to assess its potential cost-saving effects for farmers adopting this system. ImplicationsThese findings hold several implications for farmers, agronomists, and stakeholders. The increased cereal rye biomass due to delayed termination could offer greater soil benefits. While the inconsistent effects on soybean yield imply flexible termination options for cover crop adoption, the absence of substantial yield benefits underscores the importance of considering both short-term costs and long-term sustainability goals.

Granular vibration pumping system for handling and characterizing particulate materials.

A unique setup for a granular vibration pumping system was developed to ease the installation into a wide variety of granular handling processes and provide flexible options for granular physics research. Although the granular vibration pumping system can notably lift granular materials with an oscillating pipe, the climbing mechanism and related granular physics are yet to be clarified thoroughly. The new setup employs an eccentric cam mechanism as the excitation source, a linear system with dust tolerance, and a recording system, making it simple, compact, and adaptable for extending experiments. The excitation mechanism generated a clear sinusoidal vibration in the pipe, realizing better reproducibility of the climbing motions of glass beads. Moreover, the compact design facilitates the close placement of multiple pipes vibrating individually, which affects the transport performance. In addition, various types of sample cells that store particles and the imaging system allow for the detailed observation of particle motions in the pipes and even the sample cells. This developed system provides easy and accurate tuning of the existing parameters of the granular vibration pumping system, as well as new options for a further understanding of granular physics.

A supervised machine learning approach for estimating plate interface locking: Application to Central Chile

Estimating locking degree at faults is important for determining the spatial distribution of slip deficit at seismic gaps. Inverse methods of varying complexity are commonly used to estimate fault locking. Here we present an innovative approach to infer the degree of locking from surface GNSS velocities by means of supervised learning (SL) algorithms. We implemented six different SL regression methods and apply them in the Central Chile subduction. These methods were first trained on synthetic distributions of locking and then used to infer the locking from GNSS observations. We tested the performance of each algorithm and compared our results with a least squares inversion method. Our best results were obtained using the Ridge regression, which gives a root mean square error (RMSE) of 1.94 mm/yr compared to GNSS observations. The ML-based locking degree distribution is consistent with results from the EPIC Tikhonov regularized least squares inversion and previously published locking maps. Our study demonstrates the effectiveness of machine learning methods in estimating fault locking and slip, and provides flexible options for incorporating prior information to avoid slip instabilities based on the characteristics of the training set. Exploring uncertainties in the physical model during training could improve the robustness of locking estimates in future research efforts.

Integrated geo-techno-economic and real options analysis of the decision to invest in a medium enthalpy deep geothermal heating plant. A case study in Northern Belgium

Deep geothermal energy (DGE) is a renewable energy source that is considered to cause a low global warming impact. The potential of DGE for heating is widespread and interest in deep geothermal heating (DGH) has been growing in Europe to help achieving the decarbonization of the heating mix. Nevertheless, despite its large potential, DGH development in Europe remains underexplored. DGH investments are hindered by the risks born by geological and market uncertainties. However, various flexibility options inherent to the development process, such as the option to abandon or defer, could partly mitigate these risks. To account for managerial flexibility in the investment analysis, this study suggests a novel real options (RO) framework. The RO model splits DGH development into five phases, and considers several compound options and geological and market uncertainties to investigate the timing and value of DGH development at the Campine Basin in Northern Belgium. The RO model is coupled to a geo-techno-economic model and is solved using the Least Squares Monte Carlo algorithm. The RO analysis finds a 51% probability of abandonment and an average deferral time for the development of 12 years. The abandon option mitigates the risk of large financial losses in case of inadequate geological conditions. The defer option allows the investors to wait for more favorable market conditions before investing, to increase the project value. The results show that DGH development in the investigated area is not economically desirable. However, the investors' flexibility increases the project value by 12.16 million EUR, compared to a conventional techno-economic analysis. The implementation of supporting policy measures improves the economic performance of the plant. The consideration of flexibility leads to supporting policy measures with 3–4 times lower governmental expenditure, compared to a conventional techno-economic analysis. This study shows that a RO approach is more suitable to investigate DGH investments than static techno-economic methods. The inclusion of flexibility allows for identifying development pathways that increase the project value and for designing more cost-efficient supporting policy schemes.

Gamma Knife Versus Volumetric Arc Modulated Therapy in a Linear Accelerator in Treatment of Multiple Brain Metastasis: Literature Review

This literature review introduces the treatment results of Gamma Knife radiosurgery (GKRS) and volumetric arc therapy (VMAT) administered by linear accelerators for patients diagnosed with multiple brain metastases. The present study aimed to compare Gamma Knife radiosurgery with Volumetric Arc Modulated Therapy (VMAT) administered using a linear accelerator for brain metastases and their respective safety profiles and therapeutic results. The review assesses research on treatment precision, local control rates, survival outcomes, radiation necrosis incidence, and post-treatment quality of life. It evaluates technical progress, treatment plans, and physiological effects on brain tissue. Both modalities have the potential for managing brain metastases, with GKRS being beneficial for well-defined lesions and VMAT being a flexible and efficient option for larger or irregular-shaped metastases. The study highlights the unique benefits of each therapy for different types of brain metastases. GKRS and VMAT are effective treatments for brain metastases, using concentrated radiation for localised lesions and advanced imaging techniques for intricate or expanded regions. GKRS offers precise interventions with minimal invasiveness, suitable for patients with lower metastatic burdens or suboptimal surgical tolerance. Both therapies show similar effectiveness in local control and survival but may be better suited for specific patient needs and lesion characteristics

Are we working from home or office? Insights from Australia

Purpose The purpose of this paper is to explore the factors influencing office occupancy and the broader implications for workplace dynamics in Australia in the post-pandemic era. Design/methodology/approach The authors draw on industry insights, research data and expert opinions on remote work and office attendance to explain post-pandemic trends. Findings The paper finds that average office occupancy reached 71% of pre-pandemic levels in Q3 2023, indicating a significant rebound from earlier downturns. This can be explained by factors such as improved vaccination rates, clearer return-to-office policies by large corporations and a greater understanding of the virus. Originality/value This paper offers valuable insights on the implications of physical, hybrid and remote work highlighting the growing recognition of the importance of physical workspace in fostering collaboration, innovation and organisational culture. It also brings together evidence of the impact of flexible options that may support greater social and environmental sustainability.

Template-guided Silicon Micromotor Assembly for Enhanced Cell Manipulation.

Light-driven micro/nanorobots (LMNRs) are tiny, untethered machines with great potential in fields like precision medicine, nano manufacturing, and various other domains. However, their practicality hinges on developing light-manipulation strategies that combine versatile functionalities, flexible design options, and precise controllability. Our study introduces an innovative approach to construct micro/nanorobots (MNRs) by utilizing micro/nanomotors as fundamental building blocks. Inspired by silicon Metal-Insulator-Semiconductor solar cell principles, we design a new type of optomagnetic hybrid micromotors (OHMs). These OHMs have been skillfully optimized with integrated magnetic constituent, resulting in efficient light propulsion, precise magnetic navigation, and the potential for controlled assembly. One of the key features of the OHMs is their ability to exhibit diverse motion modes influenced by fracture surfaces and interactions with the environment, streamlining cargo conveyance along "micro expressway" - the predesigned microchannels. Further enhancing their versatility, a template-guided assembly strategy facilitates the assembly of these micromotors into functional microrobots, encompassing various configurations such as "V-shaped", "N-shaped", and 3D structured microrobots. The heightened capabilities of these microrobots, underscore the innovative potential inherent in hybrid micromotor design and assembly, which provides a foundational platform for the realization of multi-component microrobots. Our work moves a step toward forthcoming microrobotic entities boasting advanced functionalities.

Template‐guided Silicon Micromotor Assembly for Enhanced Cell Manipulation

Light‐driven micro/nanorobots (LMNRs) are tiny, untethered machines with great potential in fields like precision medicine, nano manufacturing, and various other domains. However, their practicality hinges on developing light‐manipulation strategies that combine versatile functionalities, flexible design options, and precise controllability. Our study introduces an innovative approach to construct micro/nanorobots (MNRs) by utilizing micro/nanomotors as fundamental building blocks. Inspired by silicon Metal‐Insulator‐Semiconductor solar cell principles, we design a new type of optomagnetic hybrid micromotors (OHMs). These OHMs have been skillfully optimized with integrated magnetic constituent, resulting in efficient light propulsion, precise magnetic navigation, and the potential for controlled assembly. One of the key features of the OHMs is their ability to exhibit diverse motion modes influenced by fracture surfaces and interactions with the environment, streamlining cargo conveyance along "micro expressway" ‐ the predesigned microchannels. Further enhancing their versatility, a template‐guided assembly strategy facilitates the assembly of these micromotors into functional microrobots, encompassing various configurations such as "V‐shaped", "N‐shaped", and 3D structured microrobots. The heightened capabilities of these microrobots, underscore the innovative potential inherent in hybrid micromotor design and assembly, which provides a foundational platform for the realization of multi‐component microrobots. Our work moves a step toward forthcoming microrobotic entities boasting advanced functionalities.

Virtual hospital care development and deployment:Arapid qualitative study of frontline clinicians and leaders.

Virtual hospitalist programs are rapidly growing in popularity due to worsening clinician shortages and increased pressure for flexible work options. These programs also have the potential to establish sustainable staffing models across multiple hospitals optimizing cost. We aimed to explore the current state of virtual hospitalist services at various health systems, challenges and opportunities that exist in providing virtual care, and future opportunities for these types of services. To identify perspectives on design and implementation of virtual hospitalist programs from academic hospitalist leaders. We conducted focus groups with United States academic hospitalist leaders. Semistructured interviews explored experiences with virtual hospitalist programs. Using rapid qualitative methods including templated summaries and matrix analysis, focus group recordings were analyzed to identify key themes. We conducted four focus groups with 13 participants representing nine hospital systems across six geographic regions and range of experience with virtual hospital medicine care. Thematic analysis identified three themes: (1) a broad spectrum of virtual care delivery; (2) adoption and acceptance of virtual care models followed the stages of diffusion of innovation; and (3) sustainability and scalability of programs were affected by unclear finances. Hospitalist leader perspectives revealed complex factors influencing virtual care adoption and implementation. Addressing concerns about care quality, financing, and training may accelerate adoption. Further research should clarify the best practices for sustainable models optimized for access, hospitalist experience, patient safety, and financial viability.

Synergies and competition: Examining flexibility options in the European electricity market

The electricity market transitions from a market clearing in which flexible generation meets inflexible demand to one in which inflexible generation meets flexible demand. Consequently, new types of flexibility are needed to balance generation and demand. This paper mainly aims to analyse competition and synergy between various flexibility options in the electricity market. The developed European electricity market model maximises the joint socio-economic welfare of the electricity and the hydrogen market. Transmission grid,- storage expansion, electric vehicle demand side flexibility and hydrogen sector coupling are flexibility options. This work examines the implementation of different flexibility options in the bidding zones Austria and Germany. Austria, with a very high storage capacity in the alpine arc and Germany, with massive wind turbine capacities serve as representative case study. Results show that the storage location heavily influences the corresponding socio-economic welfare increase. Hence, location-dependent synergy and competition between storage and transmission line expansion can occur. In contrast, sector coupled hydrogen production and storage expansion compete with each other as both will reduce very low electricity prices. Demand-side flexibility primarily benefits end-users while producer surplus reduces. In combination with storage expansion, further positive synergistic effects for end-users occur. The combination of storage expansion and demand-side flexibility can replace transmission line expansion and vice versa if used comprehensively. Further efforts could address the evaluation of these effects if the individual flexibility providers aim for something other than a system-wide but individual optimum.

Thermally Activated Building Structures as Flexibility Option for the Electricity Market

Combined with heat pumps, thermally activated building structures (TABS) can serve as a resource of flexibility for electricity markets and the grid. This paper analyses the energy-economic value resulting from utilising the flexibility enabled by thermal building inertia. The scope of the study is the Austrian building stock by the year 2040. A specific business model for using the flexibility from heat pumps in buildings is being developed in the PnP Control TABS research project. This paper also gives insights into the controller logic developed and first results from a demonstrator.

Consumer Perspectives on Commercial Pension Insurance Products: Insights and Implications

This study delves into the consumer perspectives on commercial pension insurance products, aiming to uncover insights into awareness, understanding, preferences, and concerns among consumers. Through interviews with 50 participants from five prominent Chinese insurance companies, the study examines demographic characteristics, awareness levels, perceived benefits and risks, factors influencing purchase decisions, and satisfaction with current products. The findings reveal a nuanced landscape wherein participants recognize the importance of pension insurance for long-term financial security but express apprehensions regarding policy transparency, affordability, and reliability. Trust in insurance companies, reputation, and financial stability emerge as primary factors influencing purchase decisions, highlighting the need for flexible and affordable policy options aligned with individual retirement goals. Comparative analysis among companies underscores variations in consumer perceptions, emphasizing the importance of continual product evaluation and improvement to meet evolving consumer needs. The study concludes by advocating for enhanced consumer education initiatives and regulatory frameworks to foster transparency and consumer welfare within the competitive insurance market.

CancerMHL: the database of integrating key DNA methylation, histone modifications and lncRNAs in cancer.

The discovery of key epigenetic modifications in cancer is of great significance for the study of disease biomarkers. Through the mining of epigenetic modification data relevant to cancer, some researches on epigenetic modifications are accumulating. In order to make it easier to integrate the effects of key epigenetic modifications on the related cancers, we established CancerMHL (http://www.positionprediction.cn/), which provide key DNA methylation, histone modifications and lncRNAs as well as the effect of these key epigenetic modifications on gene expression in several cancers. To facilitate data retrieval, CancerMHL offers flexible query options and filters, allowing users to access specific key epigenetic modifications according to their own needs. In addition, based on the epigenetic modification data, three online prediction tools had been offered in CancerMHL for users. CancerMHL will be a useful resource platform for further exploring novel and potential biomarkers and therapeutic targets in cancer. Database URL: http://www.positionprediction.cn/.

Shaping of Vector Beams Based on Caustic Design

AbstractAppropriate wavefront design can endow light fields with many useful properties, such as accelerating, anti‐diffracting, self‐healing, and the capability to exhibit customizable intensity shapes. The strategy of arbitrarily combining these properties to develop novel optical fields mainly relies on caustic methods. However, caustic methods have rarely been applied to the construction of vector fields. Here, slowly changing polarization information is introduced to the caustic rays, aiming to establish direct connections between conventional rays and vector beams in the physical representation. In this manner, a technique is developed to create non‐diffracting vector beams with polarization states that can vary along the caustic curves as needed. It is also demonstrated that the superposition of intersecting ray families can basically determine the polarization states of the other points in the fields. This may provide a new route for designing various novel vector fields and directly promote research in wave and focal field shaping, thereby offering more flexible beam options for applications such as material processing, particle manipulation, and microscopic imaging.